FAQ

How long until nicotine is out of my system

By PuffBye Editorial TeamLast updated Feb 2026Based on published research from CDC, WHO & NIH

Nicotine leaves your body within 48-72 hours.

Quick Answer

Nicotine leaves your body within 48-72 hours.

Detailed Explanation

Cotinine, a nicotine metabolite, takes 1-10 days. Full detoxification occurs within 2-3 weeks.

Key Facts

  • Nicotine half-life is about 2 hours
  • Cotinine is detectable for 1-10 days depending on usage

What the Research Says

CDC reports most nicotine metabolites clear within 3 days

Frequently Asked Questions

Can tests detect nicotine after 3 days
Cotinine tests may detect use for up to 10 days
Does this mean symptoms stop at 3 days
No, brain chemistry takes weeks to normalize

Sources & References

The information in this article is based on publicly available research and guidance from the following authoritative health organizations:

Sources accessed February 2026

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